“STATIC AND DYNAMIC LIGHT SCATTERING OF HEALTHY AND MALARIA-PARASITE INVADED RED BLOOD CELLS,” J BIOMED OPT 15, 020506 (2010)

Y. K. PARK, M. DIEZ-SILVA, D. FU, G. POPESCU, W. CHOI, I. BARMAN, S. SURESH, AND M. S. FELD
2010

We present the light scattering of individual Plasmodium falciparum-parasitized human red blood cells
Pf-RBCs, and demonstrate progressive alterations to the scattering signal arising from the development of malaria-inducing parasites. By selectively imaging the electric fields using quantitative phase microscopy and a Fourier transform light scattering technique, we calculate the light scattering maps of individual Pf-RBCs. We show that the onset and progression of pathological states of the Pf-RBCs can be clearly identified by the static scattering maps. Progressive changes to the biophysical properties of the Pf-RBC membrane are captured from dynamic light scattering.