Tissue imaging


SLIM imaging of breast microcalcifications. Breast tissue with calcium phosphate: SLIM image (a), color bar in nanometers; H&E image (b). The whole slice is 2.2 cm × 2.4 cm. The SLIM image is stitched by 4785 images and the H&E is stitched by 925 images. Scale bar: 100 ?m. Breast tissue with calcium oxalate: SLIM image (c), color bar in nanometers; H&E image (d). The entire slice is 1. 6 cm × 2.4 cm. The SLIM image is stitched by 2840 images and the H&E is stitched by 576 images (Z. Wang, A. Balla, K. Tangella and G. Popescu, Tissue refractive index as marker of disease, J. Biomed. Opt. 16(11), 2011)

Spatial Light Interference Microscopy (SLIM) can be used for tissue imaging and diagnosis. SLIM is capable of automatically scanning and imaging microscopy slides with tissue samples. The quantitative data obtained from Phi Optics SLIM provides insight into the condition of the tissue, whether it is in benign or malignant condition, without staining. Therefore, it allows for an automatic diagnosis of cancer in the tissue sample. Moreover, phase imaging reveals certain structures that are not readily detected in simple staining methods that are current standards in clinics that can be used as an easier and faster indicator to diagnose the condition.

 

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